Dr. James Hone, Department of Mechanical Engineering. We are an interdisciplinary research group focused on novel materials synthesis and device nano-fabrication. We use carbon nanotubes, graphene, self-assembled nanostructures, and textured substrates to study both fundamental properties and explore new applications in nano-electro-mechanical systems, biomechanical systems, nanoscale and molecular electronics and opto-electronics. The research has diverse applications in radio-frequency signal processing electronics, optical signal processing, energy generation, biological and molecular sensors, and immunology. The group is highly collaborative and works with research groups in Physics, Chemistry, Material Science, Electrical Engineering, and Mechanical Engineering.
Dr. Kenneth Shepard, Department of Electrical Engineering. The Shepard laboratory is focused on the use of integrated circuit technology for life science applications. Current research efforts include the design of active microarrays for genomics and proteomics, nanopore and nanochannel devices with integrated nanoelectronics, active multielectrode arrays for electrophysiology, and biologically powered integrated circuits. The approach behind my research is fundamentally grounded in Neural Engineering, utilizing large-scale computational modeling and advanced neuroimaging to infer circuitry and circuit properties of visual cortex. Neural engineering is an emerging interdisciplinary field of research that uses engineering techniques to investigate the function of and manipulate the behavior of the central or peripheral nervous system. There are currently 21 students and staff working in the Shepard lab.
Dr. Julio Fernandez, Department of Biological Sciences. The Fernandez laboratory has pioneered the study of protein dynamics under force, a poorly understood phenomenon that is of common occurrence in biology. ;The laboratory is interdisciplinary and combines protein engineering, software development and single molecule instrumentation, to study the folding and unfolding dynamics of the giant elastic muscle protein titin, while placed under a stretching force which is its natural mode of operating in vivo.
Dr. Jingyue Ju, Chemical Engineering/Columbia Genome Center. The Ju laboratory focuses on the design and synthesis of novel molecular tags for biological labeling and imaging, and developing new technologies to study problems in genomics. They are pursuing these research objectives by using chemical science, engineering principles and experimental biological approaches. They have pioneered the use of chemistry and fluorescence energy transfer (ET) principles to construct ET molecular tags for high-throughput genomic research. The ET tags facilitated the rapid development of laser induced fluorescence capillary-array DNA sequencers, which are the major driving force for completion of the international Human Genome Project.
Dr. Latha Venkataraman, Department of Applied Physics & Applied Mathematics. The Venkataraman laboratory focuses on understanding fundamental electronic, mechanical and thermal properties of single molecule circuits, consisting of a molecule attached to two metal electrodes. They fabricate these devices, with varied functionality, where the circuit structure is defined with atomic precision and measure how electronic conduction and single bond breaking forces in these devices relate not only to the molecular structure, but also to the metal contacts and linking bonds. Their experiments provide a deeper understanding of the fundamental physics of electron transport, while laying the groundwork for technological advances at the nanometer scale.
Dr. Wei Min, Department of Chemistry. Biophotonics is one of the fastest growing fields at the interface of physical science and life science. The newly emerging optical microscopy tools promise to make major contributions in unraveling biological processes that are localized in space, dynamic in time, and complex in nature. The Min group is dedicated to develop novel and powerful optical bio-imaging and spectroscopy techniques and to apply them to visualize and understand dynamic behaviors of bio-molecules and their delicate interactions in living cells and organisms.
Dr. Ozgur Sahin, Department of Biological Sciences and Department of Physics. The Sahin laboratory investigates biological systems that function under physical extremes like short timescales, confinement to nanoscale regions of space, and high mechanical forces. They frequently develop new experimental methods to carry out our research. Quite often, they encounter interesting phenomena in biological systems that they enjoy applying to medical, environmental, and energy related problems.
Dr. Rafael Yuste, Departments of Biological Sciences and of Neuroscience. The Yuste laboratory studies the structure and function of cortical circuits using advanced optical and biophysical approaches. By imaging and manipulating the activity of neurons in living mouse brains, the group attempts to decipher the function of the mammalian neocortex and understand how dendritic spines contribute to the circuit function. This work could lead to better understanding of the pathophysiology of epilepsy and schizophrenia. In addition, the Yuste lab is pioneering the use of the Cnidarian Hydra vulgaris as a model system for the comprehensive measuring of all neural activity in an animal during its behaviour. The Yuste group also helped inspire the White House's BRAIN initiative, a large-scale scientic project to develop new methods for Neuroscience. There are currently 22 students and staff working in the Yuste lab.
Paul Sajda, Department of Biomedical Engineering, Radiology (Physics) and Electrical Enginnering. Neurocomputational modeling and neuroengineering, pattern recognition, adaptive processing for biomedical image and signal analysis.
Xiaofan "Fred" Jiang, Department of Electrical Engineering. Cyber physical systems and data analytics, smart and sustainable buildings, mobile and wearable systems, environmental monitoring and control, and connected health & fitness.
James Teherani, Department of Electrical Engineering. Emerging materials and devices (e.g. 2D transition metal dichalcogenides), strain engineering, high-mobility transistors, tunneling transistors (TFETs), and quantum device structures.
Michael P. Burke, Department of Mechanical Engineering. His primary research interests lie at the intersection of diverse areas—multi-scale modeling, data sciences, and automation—applied to mixed-experimental-and-computational investigations of complex reaction networks and reacting flows of advanced combustion and energy applications.
Franck Polleux, Department of Neuroscience. Throughout his career, Dr Polleux has focused on the identification of the molecular mechanisms underlying neuronal development in the mammalian brain. More recently, his lab also started studying the genetic basis of human brain evolution as well as the signaling pathways underlying synaptic loss during early stages of Alzheimer’s Disease progression.
Dr. Stavros Lomvardas, Department of Pathology and Cell Biology. Our research program aims to understand the molecular mechanisms of olfactory receptor gene choice. Olfactory receptor (OR) genes compose the largest mammalian gene family consisted of more than 1000 members. These genes are expressed in a stochastic and mutually exclusive fashion in such a way that only one OR allele is expressed in each olfactory sensory neuron. Our data suggest that this unusual expression pattern is orchestrated by a combination of positive and negative regulatory mechanism. According to our findings, OR genes undergo chromatin mediated silencing at a developmental stage that precedes olfactory receptor activation. One of the 3000 alleles is chosen for activation, by the enzymatic removal of the silencing chromatin marks. We currently combine genetic and biochemical approaches that together with cutting edge microscopy should reveal critical mechanistic details of this process.
Dr. Virginia Cornish, Department of Chemistry. Synthetic Biology aims to engineer artificial pathways in cells both to test fundamental notions of how complex biological networks function and to develop new technologies for the treatment of disease. Moving beyond advances in the last century for the synthetic manipulation of biomolecules in vitro, the Cornish laboratory is creating conceptually new approaches for the modification of biomolecules in a living cell. As opposed to designing molecules that can be added to the cell with minimal perturbation of its natural functions, their approach is to design molecules capable of co-opting the cell's own highly evolved and integrated synthetic machinery (evolution and translation) for production of the modified biomolecules in vivo. Finally, they are using these new synthetic methods to develop tools for live cell imaging. There are currently 12 students and staff working in the Cornish laboratory.
Dr. Brent Stockwell, Howard Hughes Medical Institute, Department of Biological Sciences and Department of Chemistry. The Stockwell laboratory is exploring two biological questions using chemical tools. First, what is the full range of cell death processes, and how are these processes regulated. In this context, we discovered an alternative form of cell death that we termed ferroptosis, for its critical reliance on cellular iron. We are examining the mechanism of this form of cell death, as well its relevance to numerous diseases. Second, we are testing the notion that 85% of proteins are resistant to small molecule modulation by using a computational design strategy to create small molecule inhibitors of these historically undruggable proteins. This would have profound ramifications for drug discovery and medicine. There are currently ~20 students and staff working in the Stockwell laboratory.
Dr. Luis Campos, Department of Chemistry. The Campos research group is interested in exploring nanostructured materials for the development of advanced functional systems. We take advantage of macromolecular structures that can be finely tuned through molecular design and robust synthetic strategies. The interdisciplinary nature of our work allows the group to build strengths in synthesis, device fabrication, and fundamental design and characterization of the materials from form to function.
Dr. Xiaoyang Zhu, Department of Chemistry. We are interested in the general problem of light-condensed matter interaction. A main research thrust is to establish new photophysical mechanisms that may be utilized to revolutionize solar energy conversion or light emission. As examples, recent discoveries in our lab showed how an electron and a hole is bound by the Coulomb potential across an organic semiconductor interface, how an exciton can split into two via the singlet fission process, and how hybrid semiconductors can yield the highest possible quantum efficiency in light emission.
Kathleen McKeown, Department of Computer Science. A leading scholar and researcher in the field of natural language processing, Kathleen R. McKeownfocuses her research on big data; her interests include text summarization, question answering, natural language generation, multimedia explanation, digital libraries, and multilingual applications. Her research groups Columbia Newsblaster, which has been live since 2001, is an online system that automatically tracks the day's news, and demonstrates the groups new technologies for multi-document summarization, clustering, and text categorization, among others. Currently, she leads a large research project involving prediction of technology emergence from a large collection of journal articles.
Patricia Culligan, Department of Civil Engineering and Engineering Mechanics. A leader in the field of water resources and urban sustainability, Culligan has worked extensively withThe Earth Institute's Urban Design Lab at Columbia University to explore novel, interdisciplinary solutions to the modern day challenges of urbanization, with a particular emphasis on the City of New York. Culligan is the director of a joint interdisciplinary Ph.D. program between Columbia Engineering and the Graduate School of Architecture Planning and Preservation that focuses on designs for future cities, including digital city scenarios. Her research group is active in investigating the opportunities for green infrastructure, social networks and advanced measurement and sensing technologies to improve urban water, energy, and environmental management